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Inventory of Bone Substitute Materials
Medical polymer materials 2025-03-27 15:39:35

Bone substitute materials, also known as bone graft substitutes or bone regeneration materials, are used in orthopedic and dental surgeries to replace natural bone. These materials are designed to support, enhance, or promote the regeneration and repair of damaged or missing bone tissue. The primary function of bone substitute materials is to provide a scaffold structure that facilitates the formation of new bone, which is eventually replaced or integrated by new bone tissue.

Here are some typical products in each category:
Bone screws: used to fix fracture fragments or as tension screws to hold fracture pieces together. Common types include PDLLA/HA composite absorbable bone screws and metal titanium alloy bone screws.
Bone plates: closely attached to the bone to provide fixation, used in conjunction with screws for internal fixation of fractures, including straight and non-straight metal bone plates, as well as specially shaped bone plates such as triangular, curved, and L-shaped.

The commonly used materials for orthopedic plates mainly include the following types:

Stainless steel:

With high mechanical performance and low price.

The anti-corrosion ability in the body is generally poor.

Cobalt alloys:

More corrosion-resistant and almost completely inert to tissues.

The mechanical properties are not as good as stainless steel.

3. Titanium alloy:

It has good toughness and fracture resistance.

Good organizational compatibility, elastic modulus close to that of bone.

The price is relatively high.

4. Carbon fiber reinforced polyether ether ketone composite plate (CF-PEEK):

Through technological innovation, carbon within the board layers is embedded in PEEK in different directions to form a new composite material.

The elastic modulus has only slightly increased, but the stiffness and strength have greatly improved.

According to different ratios of carbon fiber, they are divided into CF30, CF50, and CF60, which have been successively applied in the field of spinal trauma and other areas.

Intramedullary nails: used for internal fixation of fractures, especially diaphyseal fractures of long bones, such as V-shaped intramedullary nails, flower-shaped intramedullary nails, and locking intramedullary nails, etc.

Spinal implants: used for stabilization and fusion of the spine, including interbody fusion devices, spinal fixation systems (such as pedicle screw systems), artificial intervertebral discs, etc.

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The commonly used materials for spinal implants include the following:

Metal materials

Titanium alloy: Titanium alloy is the mainstream metal material for manufacturing spinal interbody fusion devices, possessing good biocompatibility and biosafety. Additive manufacturing technology (3D printing) has accelerated the development of titanium alloy fusion devices, allowing for the adjustment of pore sizes to achieve an elastic modulus similar to that of bone, thereby improving bone integration.
Porous tantalum metal: Porous tantalum metal fusion devices are also materials that have gained attention in recent years, characterized by good biocompatibility and the effect of biomimetic metallic bone trabeculae.

2. Bioactive materials

Calcium phosphate materials: including hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and a mixture of both (biphasic calcium phosphate, BCP). These materials are commonly used for non-structural bone grafting.

Bioactive glass (BAG): It has good bioactivity and can promote the regeneration of new tissues.

Composite materials such as nano-hydroxyapatite/polyamide 66 composites (n-HA/PA66) and coral hydroxyapatite (CHA) are commonly used in intervertebral fusion devices, offering good biocompatibility and mechanical properties.

3. Polymer Materials

PEEK is currently the best material for intervertebral fusion devices and has to some extent replaced titanium, gaining widespread recognition among orthopedic surgeons. The characteristics of PEEK include a modulus of elasticity close to that of bone tissue, mechanical properties similar to cortical bone, minimal stress shielding, and good radiolucency, which facilitates imaging observation.

Biodegradable materials

Polylactic acid: used to manufacture biodegradable interbody fusion devices, with a degradation rate that approximately matches the time required for bone tissue reconstruction and repair, exhibiting good biocompatibility.
Artificial joint prostheses: artificial hip joint, artificial knee joint, artificial shoulder joint, artificial elbow joint, artificial ankle joint, artificial wrist joint, artificial finger joint, etc. Among them, artificial hip joint and artificial knee joint are the most developed and widely used.

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Common total knee prostheses

The commonly used materials for artificial joint prostheses mainly include metal materials, polymer materials, and ceramic materials. The following are the specific applications and characteristics of these three types of materials:

Metal materials

Stainless steel: Although it was widely used in artificial joint prosthetics in the early days, it has gradually been replaced by more advanced materials due to the presence of elements, such as nickel, that may cause distortion.

Cobalt-based alloys and titanium alloys: These materials have excellent mechanical properties and stability, and are gradually becoming the preferred materials for modern artificial joint prostheses.

Polymeric Materials

Ultra-high molecular weight polyethylene: commonly used in the manufacture of joint surfaces, such as acetabular cup liners, it has excellent wear resistance, stress crack resistance, and self-lubricating properties. It is an indispensable material in hip and knee joint replacements.
Other common polymer materials include polyether ether ketone (PEEK) and polymethyl methacrylate (PMMA).

3. Ceramic Materials

Ceramics: Such as alumina and zirconia ceramics, which have good biocompatibility and low wear rate, but have high manufacturing costs and may exhibit brittleness in certain cases.

These orthopedic implants have a wide range of applications in clinical practice, providing stable fixation and support to help restore the structure and function of bones. With advancements in biomaterials and manufacturing technology, the design and materials of these implants are continually being optimized to improve their biocompatibility, mechanical properties, and ability to promote bone healing.

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